9 Biotech Startups Vying for $100K That Could Redefine Medicine

Virus-proof organs and nanotechnology powder that stops bleeding instantly. This isn't science fiction; it's the reality being built by startups at TechCrunch's annual Startup Battlefield competition. Whittled down from thousands of applicants, these elite companies are competing for a $100,000 grand prize and a chance to reshape their industries.

This year, nine companies in the biotech and pharma space stood out, showcasing the potential to fundamentally alter human health and longevity. From gene-editing and AI diagnostics to next-generation medical devices, their technologies are pushing the boundaries of what’s possible in medicine.

Targeting Disease at its Source with AI and CRISPR

A clear theme among the finalists was tackling the root causes of illness. CasNx has developed a CRISPR gene-editing kit that eliminates viruses from donor organs and installs “universal donor” markers, a development that could dramatically improve transplant success rates. Nephrogen is taking it a step further, using AI to precisely target gene-editing therapies to the specific cells in the kidney causing disease.

In diagnostics, accessibility and personalization are key. Exactics aims to empower consumers with at-home rapid diagnostic tests, starting with Lyme disease. Meanwhile, Reme-D is developing affordable tests that remain stable in hot and humid climates, specifically targeting underserved communities.

Reinventing Hardware and Novel Treatments

The innovation wasn't limited to software and genetics. Chipiron is building a lightweight and inexpensive full-body MRI machine using superconducting quantum interference devices (SQUID), making cancer diagnostics far more accessible. In emergency medicine, Miraqules has created a nanotechnology powder that mimics blood-clotting proteins to provide instant hemostasis, a potentially lifesaving tool for first responders.

Other standouts include Surgicure Technologies, with a patented device to more safely secure endotracheal tubes; Lumos Strategies with its consumer electromagnetic device, Avara, designed to improve sleep and recovery; and PraxisPro, an AI-powered training system for life science sales roles.